Betty White, the quick-witted comedienne whose ribald humor as showcased on The Mary Tyler Moore Show, The Golden Girls and Hot in Cleveland made her America’s ageless darling, has died. She was 99.

The beloved five-time Emmy Award winner and animal advocate, whose career reached another level after she became an octogenarian, died at home on Friday (Dec. 31), her agent told People magazine.

White joined the cast of The Mary Tyler Moore Show for the CBS sitcom’s fourth season in 1973 as Sue Ann Nivens, the blunt, man-lusting star of the WJM-TV show The Happy Homemaker, and she won two straight Emmys for outstanding continuing performance by a supporting actress in a comedy series.

On NBC’s The Golden Girls, which aired for seven seasons, White played the simple-minded Minnesotan Rose Nylund opposite Bea Arthur, Rue McClanahan and Estelle Getty. She was nominated for lead comedy series actress in every year from 1986 through 1992, winning the trophy in her first try.

And on TV Land’s Hot in Cleveland, which completed its six-season run in 2015, White was cast in her late 80s as the sharp-tongued Elka Ostrovsky, who takes care of the Victorian home inhabited by L.A. transplants played by Valerie Bertinelli, Jane Leeves and Wendie Malick. That earned her a supporting actress Emmy nom in 2011.

“Betty White is one of the few people who walks into the room and you know her,” Carl Reiner said on the 2018 PBS special Betty White: First Lady of Television. “You’ve known her all your life. She’s one of those people that are always welcome on any show she’s on.”

Earlier in her career, her snappy banter and dizzy smile made her a popular guest on such game shows as To Tell the Truth, What’s My Line?, Match Game, Password and Liar’s Club — the last two hosted by her husband, the late Allen Ludden. (They met when she was on Password in 1961.)

She also won a Daytime Emmy in 1983 for hosting the game show Just Men!, the first awarded to a female emcee.

White won another Emmy and attracted 12 million viewers for hosting Saturday Night Live in 2010 at age 88 after a fan-based Facebook campaign; starred in a clever Snickers Super Bowl commercial with Abe Vigoda; and netted noms from 2012-14 (giving her a career total of 21) as host of the NBC reality show Off Their Rockers.

In 1988, White was inducted into the Television Hall of Fame and received the Screen Actors Guild’s Life Achievement Award in 2010.

The Guinness Book of World Records in 2013 said she held the record for longest TV career for an entertainer (female). “I think the reason for the longevity is that several generations have gotten to know me over the years, so I’ve become sort of part of the family,” she told Larry King in 2010.

Betty Marion White was born on Jan. 17, 1922, in Oak Park, Illinois, the only child of an electrical engineer and a housewife. The family moved to Los Angeles when she was 2, and she graduated from Beverly Hills High School. Her idol was singer-actress Jeanette MacDonald.

“I was in the graduation play from high school and the president of our senior class, and I sang ‘The Merry Widow’ and did a little dance,” White told NPR in a 2014 interview. “I think that’s when the showbiz bug bit me — and they haven’t been able to get rid of me since.”

She landed parts on radio shows and in 1949 accepted disc jockey Al Jarvis’ offer to be his “Girl Friday” on Hollywood on Television, a new variety show he was doing for KLAC-TV. The show was on for 5½ hours a day, six days a week (Sundays off!). When Jarvis departed in 1952, she hosted the show for a couple of years.

Also in 1952, the adorable White co-founded Bandy Productions — she was a rare woman with power in show business in those days — and went on to star as the title character in the syndicated sitcom Life With Elizabeth, shot live from the Music Hall Theater in Beverly Hills. She also hosted The Betty White Show in daytime for NBC (that was only on a half-hour each weekday) and played a newlywed in Date With the Angels, a 1957-58 ABC comedy.

Following The Mary Tyler Moore Show, White starred in another series called The Betty White Show, this one a short-lived sitcom from CBS/MTM Enterprises. She played a TV actress starring in a police series who was directed by her character’s ex-husband (John Hillerman).

In the 1980s, White recurred as Ellen Harper Jackson, the oldest daughter of Thelma (Vicki Lawrence), on Mama’s Family, and showed up as Rose on the series Empty Nest, the short-lived Golden Girls spinoff The Golden Palace and Nurses.

White was a regular on CBS’ Bob, starring Bob Newhart (the actors’ characters would get married on the Hot in Cleveland finale); played the mother of Marie Osmond on the ABC sitcom Maybe This Time in 1995; won an Emmy for playing herself on The John Larroquete Show; and was Alfred Molina’s mom on the 1999-2001 CBS sitcom Ladies Man.

She played Catherine Piper, a childhood friend and blackmailer of William Shatner’s Denny Crain, on The Practice and Boston Legal and portrayed the rude Bea Sigurdson on That ’70s Show. Other notable guest-starring appearances came on St. Elsewhere; Suddenly Susan; Yes, Dear; My Name Is Earl; 30 Rock; Community; and The Middle.

In films, she played a senator from Kansas in Otto Preminger’s Advise & Consent (1962), was the foul-mouthed Delores Bickerman in Lake Placid (1999) and played Ryan Reynolds’ outlandish grandmother in The Proposal (2009). She also appeared in the comedies The Story of Us (1999), Bringing Down the House (2003) and You Again (2010).

She turned down the role of Helen Hunt’s mother in As Good as It Gets (1997) because she objected to a scene in which a dog is thrown down a rubbish chute.

“Of course it lands on some cushions and it’s fine, but I didn’t want to set that example, because you never know what nuts or kids will see it and think I can do that,” she said on The Tonight Show. “The director said, ‘The dog’s fine, the dog’s fine!’ But I said, ‘I just can’t do that.’ ”

White worked on many charitable projections involving animal disease research. She served for three years as the president of the Morris Animal Foundation and served on the board of trustees for the Greater Los Angeles Zoo Assn.

She was married to Ludden, her third husband, from 1963 until his death from cancer in 1981.

Duane Byrge contributed to this report.

This article was originally published by The Hollywood Reporter.